000 04770nam a22004697a 4500
001 ACM011452625848
003 APU
005 20221028161927.0
008 220307t20142014nyua b 000 0deng d
020 _a9781627055055 (pdf)
020 _z9781627055062 (epub)
020 _z9781627055437 (hardbook)
020 _z9781627055048 (paperback)
035 _a(OCoLC)908155772
035 _a(CaBNVSL)swl00404866
040 _aCaBNVSL
_beng
_cAPU
_dSF
050 4 _aGV1469.34.S3
_bC66 2014eb
082 0 4 _a794.8
_223
100 1 _aCooper, Seth,
_d1982-,
_947382
245 1 2 _aA framework for scientific discovery through video games
_h[electronic resource] /
_cSeth Cooper.
260 _a[New York] ;
_a[San Rafael, California] :
_bMorgan & Claypool,
_cc2014.
300 _a1 online resources (xiv, 117 pages) :
_billustrations.
490 1 _aACM books ;
_v#3
504 _aIncludes bibliographical references (pages 111-117).
505 0 _a1. Introduction -- 1.1 Motivation -- 1.2 Problem statement -- 1.2.1 Game design problem -- 1.2.2 Biochemistry discovery problem -- 1.3 Outline --
505 8 _a2. Related literature -- 2.1 Volunteer computing and human computation -- 2.2 Serious games and gamification -- 2.3 Computational biochemistry --
505 8 _a3. Framework -- 3.1 Introduction -- 3.2 Biochemistry background -- 3.3 Framework description -- 3.3.1 Architecture -- 3.3.2 Coevolution strategy -- 3.3.3 Categorization as a game -- 3.4 Game design challenges -- 3.4.1 Visualizations -- 3.4.2 Interactions -- 3.4.3 Scoring -- 3.4.4 Introductory levels -- 3.5 Rewards and social interaction -- 3.5.1 Rewards and ranking types -- 3.6 Conclusion --
505 8 _a4. Protein structure prediction -- 4.1 Introduction -- 4.2 Quest to the natives -- 4.3 CASP8 experiments -- 4.4 Evaluation -- 4.5 Rebuild and refine comparison -- 4.5.1 First strand swap example -- 4.5.2 Player contribution and expertise -- 4.6 Alignment tool and CASP9 -- 4.7 Solution of crystal structure -- 4.8 Conclusion --
505 8 _a5. Protein design -- 5.1 Introduction -- 5.2 Framework extension -- 5.2.1 Foldit -- 5.2.2 Iteration strategy -- 5.3 Science transfer -- 5.3.1 Visualizations -- 5.3.2 Tools -- 5.3.3 Conditions -- 5.4 Introductory levels -- 5.5 Examples -- 5.5.1 Fibronectin -- 5.5.2 Diels-Alder -- 5.6 Conclusion --
505 8 _a6. Protein structure refinement algorithms -- 6.1 Introduction -- 6.2 Related work -- 6.3 Overview -- 6.3.1 Cookbook -- 6.4 CASP9 analysis -- 6.4.1 Recipe sharing -- 6.4.2 Inheritance relationships -- 6.4.3 Ratings -- 6.5 Script recipe adoption analysis -- 6.6 Algorithm categories -- 6.7 Context dependence -- 6.8 Recipe evolution -- 6.9 Performance comparison -- 6.10 Conclusion --
505 8 _a7. Conclusion -- 7.1 Contributions -- 7.2 Future work -- Bibliography -- Author's biography.
506 _aAbstract freely available; full-text restricted to subscribers or individual document purchasers.
520 3 _aWhen we first set out to create Foldit over six years ago, it wasn't clear that a game-based approach to scientific discovery would work. So we planned from the start for the game to be continually adapting and changing, in order to keep improving based on the lessons we'd learn. It took several years of design, development, and continued iteration from a team of computer scientists and biochemists until the game was at a point where we made our first exciting discovery. The nature of the challenging problems we were facing required this time and refinement to solve. We are now seeing a number of other games that allow players to contribute to scientific research. Much of this growth has been in fields related to biology and biochemistry: EteRNA for designing RNA shapes, EyeWire for mapping neurons, and Phylo for aligning genetic sequences. Each of these games has had exciting scientific results produced by game play. Games are being applied in other areas as well, such as in the Algoraph suite of games for solving graph theory problems. I have been involved in the development of two more science games: Nanocrafter, which aims to push the frontiers of DNA-based synthetic biology, and Flow Jam, which allows players to help formally verify software.
538 _aMode of access: World Wide Web.
538 _aSystem requirements: Internet connectivity; World Wide Web browser and Adobe Acrobat Reader.
650 0 _aVideo games
_xScientific applications.
_947383
650 0 _aFoldit (Game)
_947384
650 0 _aProtein folding
_xComputer simulation.
_947385
830 0 _aACM books ;
_v#3.
_947379
856 4 8 _uhttps://dl-acm-org.ezproxy.apu.edu.my/doi/book/10.1145/2625848
_zAvailable in ACM Digital Library. Requires Log In to view full text.
942 _2lcc
_cE-Book
999 _c383689
_d383689